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Familial episodic Ataxia:Clinical Heterogeneity in Four Families Linked to Chromosome 19p Ann Neurol 41:8-16, 41997., Baloh,R.W.,et al, 1997 See this aricle in Pubmed Article Abstract We describe the clinical and oculographic findings in 4 families with episodic ataxia and interictal nystagmus(EA-2)linked to chromosome 10p. Episodes varied from pure ataxia to combinations of symptoms suggesting involvement of the cerebellum,brainstem,and cortex.Some affected individuals exhibited a progressive ataxia syndrome phenotypically indistinguishable from the dominantly inherited spinocerebellar ataxia (SCA)syndromes.About one-half of the affected individuals had migraine headaches and several had episodes typical of basilar migraine. Oculographic findings were localizing to the vestibulocerebellum and posterior vermis.Additional genetic and environmental factors must account for the marked clinical heterogeneity in those families with an abnormal gene on chromosome 19p.

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(click to filter results - removes previous filter) ataxia,hereditary ataxia,paroxysmal chromosome 19 familial hemiplegic migraine familial periodic ataxia headache migraine migraine,hemiplegic neuroophthalmology nystagmus paroxysmal neurologic deficits

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